Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme
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Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme

  • Author(s): Nikanjam, Mina
  • Blakely, Eleanor A.
  • Bjornstad, Kathleen A.
  • Shu, Xiao
  • Budinger, Thomas F.
  • Forte, Trudy M.
  • et al.
Abstract

This paper discribes a synthetic low density lipoprotein (LDL) made by complexing a 29 amino acid that consists of a lipid binding domain and the LDL receptor binding domain with a lipid microemulsion. The nano-LDL particles were intermdiate in size between LDL and HDL and bound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDL uptake by GBM cells was LDL receptor specific and dependent on cell receptor number. It is suggested that these synthetic particles can serve as a delivery vehicle for hydophobic anti-tumor drugs by targeting the LDL receptor.

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