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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
- Author(s): Miyagawa, Toji
- Brushaber, Danielle
- Syrjanen, Jeremy
- Kremers, Walter
- Fields, Julie
- Forsberg, Leah K
- Heuer, Hilary W
- Knopman, David
- Kornak, John
- Boxer, Adam
- Rosen, Howie
- Boeve, Bradley
- ARTFL/LEFFTDS Consortium
- et al.
Published Web Locationhttps://pubmed.ncbi.nlm.nih.gov/31477517/?from_term=+Use+of+the+CDR%C2%AE+plus+NACC+FTLD+in+mild+FTLD%3A+Data+from+the+ARTFL%2FLEFFTDS+consortium.&from_pos=1
No data is associated with this publication.
IntroductionBehavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR® plus NACC FTLD).
MethodsWe analyzed the CDR® plus NACC FTLD among participants from the baseline visit of the Advancing Research and Treatment for Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Consortium.
ResultsThe CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB) = 0. The CDR®-SB was not sensitive, particularly in participants with mild nonfluent/agrammatic primary progressive aphasia. Participants with familial and sporadic behavioral variant FTD exhibited similar CDR® plus NACC FTLD profiles except that language impairment was more frequent in participants with mild sporadic behavioral variant FTD. Adding the BEHAV and/or LANG domains to the CDR®-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders.
DiscussionThe BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.
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