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Structural dynamics and DNA interaction of human TFIID

  • Author(s): Nogales, E
  • Fang, J
  • Louder, RK
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279711/
No data is associated with this publication.
Abstract

© 2017 The Author(s). Published with license by Taylor & Francis © 2017, © Eva Nogales, Jie Fang, and Robert K. Louder. TFIID is a large protein complex required for the recognition and binding of eukaryotic gene core promoter sequences and for the recruitment of the rest of the general transcription factors involved in initiation of eukaryotic protein gene transcription. Cryo-electron microscopy studies have demonstrated the conformational complexity of human TFIID, where one-third of the mass of the complex can shift its position by well over 100 Å. This conformational plasticity appears to be linked to the capacity of TFIID to bind DNA, and suggests how it would allow both the recognition of different core promoter elements and the tuning of its binding affinity by regulatory factors.

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