UC Santa Cruz

Technological and computational advances in analysis of cell size have led to new insights into mammalian size control. These new techniques have allowed high-resolution, single-cell measurement of size in large numbers of proliferating cells, which allowed testing of models of cell size control. Here, I will describe the techniques used, and put the data generated into context for the established models of size control that are currently under debate. After a comprehensive study of the literature these techniques support an adder model of growth control in mammalian cells, in which there is a constant amount of growth generated per cell cycle, regardless of starting cell size.