Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs
- Author(s): Verkman, Alan
- Jin, BJ
- Thiagarajah, JR
- Verkman, AS
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3557305?pdf=render
Secretory diarrheas such as cholera are a major cause of morbidity and mortality in developing countries. We previously introduced the concept of antisecretory therapy for diarrhea using chloride channel inhibitors targeting the cystic fibrosis transmembra