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Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs

  • Author(s): Verkman, Alan
  • Jin, BJ
  • Thiagarajah, JR
  • Verkman, AS
  • et al.

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Secretory diarrheas such as cholera are a major cause of morbidity and mortality in developing countries. We previously introduced the concept of antisecretory therapy for diarrhea using chloride channel inhibitors targeting the cystic fibrosis transmembra

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