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Open Access Publications from the University of California

Clozapine Intoxication Mimicking Acute Stroke

  • Author(s): Lebin, Jacob A.
  • Villarreal, Joshua D.
  • Chen, Betty C.
  • Hall, M. Kennedy
  • et al.

Clozapine is an atypical antipsychotic drug prescribed for treatment-resistant schizophrenia. The risk of adverse hematologic, cardiovascular, and neurologic effects has tempered its use, and reports of overdoses remain rare. We report a case of accidental acute clozapine intoxication in a clozapine-naïve patient, who presented with symptoms mimicking acute stroke and later developed status epilepticus. Clozapine intoxication is a rare presentation in the emergency department with potential for iatrogenic harm if not correctly identified.

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