Clinical Practice and Cases in Emergency Medicine
Clozapine Intoxication Mimicking Acute Stroke
- Author(s): Lebin, Jacob A.
- Villarreal, Joshua D.
- Chen, Betty C.
- Hall, M. Kennedy
- et al.
Published Web Locationhttps://doi.org/10.5811/cpcem.2018.1.36734
Clozapine is an atypical antipsychotic drug prescribed for treatment-resistant schizophrenia. The risk of adverse hematologic, cardiovascular, and neurologic effects has tempered its use, and reports of overdoses remain rare. We report a case of accidental acute clozapine intoxication in a clozapine-naïve patient, who presented with symptoms mimicking acute stroke and later developed status epilepticus. Clozapine intoxication is a rare presentation in the emergency department with potential for iatrogenic harm if not correctly identified.