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Open Access Publications from the University of California

Antiretroviral Treatment Simplification With 2-Drug Regimens: Impact of Transmitted Drug Resistance Mutations.

  • Author(s): Kessler, Harald H
  • Stelzl, Evelyn
  • Blažič, Anja
  • Mehta, Sanjay R
  • Benezeder, Anna S
  • Genger-Hackl, Christina
  • Santner, Brigitte I
  • Chaillon, Antoine
  • Hoenigl, Martin
  • et al.

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The frequency of clinically relevant transmitted drug resistance mutations (DRMs) against drugs used for 2-drug regimens was 15.6%, but only 2% were not eligible for 1 or more 2-drug regimens. More than 50% of patients harboring any clinically relevant DRMs were found to be part of genetic transmission clusters.

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