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Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells”
- Bilican, Bilada;
- Serio, Andrea;
- Barmada, Sami J;
- Nishimura, Agnes Lumi;
- Sullivan, Gareth J;
- Carrasco, Monica;
- Phatnani, Hemali P;
- Puddifoot, Clare A;
- Story, David;
- Fletcher, Judy;
- Park, In-Hyun;
- Friedman, Brad A;
- Daley, George Q;
- Wyllie, David JA;
- Hardingham, Giles E;
- Wilmut, Ian;
- Finkbeiner, Steven;
- Maniatis, Tom;
- Shaw, Christopher E;
- Chandran, Siddharthan
- et al.
Published Web Location
https://doi.org/10.1126/scitranslmed.3005065Abstract
Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.
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