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PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
- Gordon, Sydney R;
- Maute, Roy L;
- Dulken, Ben W;
- Hutter, Gregor;
- George, Benson M;
- McCracken, Melissa N;
- Gupta, Rohit;
- Tsai, Jonathan M;
- Sinha, Rahul;
- Corey, Daniel;
- Ring, Aaron M;
- Connolly, Andrew J;
- Weissman, Irving L
Published Web Location
https://doi.org/10.1038/nature22396Abstract
Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast, PD-L1 removal increases phagocytosis in vivo, decreases tumour burden and increases survival of mice.
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