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Euo is a developmental regulator that represses late genes and activates midcycle genes in Chlamydia trachomatis
- Hakiem, Owais R;
- Rizvi, Syed MA;
- Ramirez, Cuper;
- Tan, Ming
- Editor(s): Babitzke, Paul
Published Web Location
https://doi.org/10.1128/mbio.00465-23Abstract
Importance
In this study, we developed a correlative approach that combined DNA immunoprecipitation-seq and RNA-seq analyses to define the regulon of the Chlamydia trachomatis transcription factor Euo. We confirmed the proposed role of Euo as a transcriptional repressor of late chlamydial genes but also showed that Euo activates transcription of a subset of midcycle genes and autoregulates its own expression via negative feedback. This study validates and expands the role of Euo as an important developmental regulator in C. trachomatis. In addition, this genome-wide correlative approach can be applied to study transcription factors in other pathogenic bacteria.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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