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ERADicating stem cells from their niche.

Published Web Location

https://doi.org/10.1038/s41556-020-00585-7
Abstract

Protein homeostasis preserves stem cell function, but underlying mechanisms are largely unknown. A study reveals that protein quality control mediated by the endoplasmic reticulum-associated degradation pathway ensures proper expression of MPL, a key cell surface receptor that promotes haematopoietic stem cell function through niche interaction.

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