Skip to main content
Genome‐Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent
- Smith, Caren E;
- Follis, Jack L;
- Dashti, Hassan S;
- Tanaka, Toshiko;
- Graff, Mariaelisa;
- Fretts, Amanda M;
- Kilpeläinen, Tuomas O;
- Wojczynski, Mary K;
- Richardson, Kris;
- Nalls, Mike A;
- Schulz, Christina‐Alexandra;
- Liu, Yongmei;
- Frazier‐Wood, Alexis C;
- van Eekelen, Esther;
- Wang, Carol;
- de Vries, Paul S;
- Mikkilä, Vera;
- Rohde, Rebecca;
- Psaty, Bruce M;
- Hansen, Torben;
- Feitosa, Mary F;
- Lai, Chao‐Qiang;
- Houston, Denise K;
- Ferruci, Luigi;
- Ericson, Ulrika;
- Wang, Zhe;
- de Mutsert, Renée;
- Oddy, Wendy H;
- de Jonge, Ester AL;
- Seppälä, Ilkka;
- Justice, Anne E;
- Lemaitre, Rozenn N;
- Sørensen, Thorkild IA;
- Province, Michael A;
- Parnell, Laurence D;
- Garcia, Melissa E;
- Bandinelli, Stefania;
- Orho‐Melander, Marju;
- Rich, Stephen S;
- Rosendaal, Frits R;
- Pennell, Craig E;
- Jong, Jessica C Kiefte‐de;
- Kähönen, Mika;
- Young, Kristin L;
- Pedersen, Oluf;
- Aslibekyan, Stella;
- Rotter, Jerome I;
- Mook‐Kanamori, Dennis O;
- Zillikens, M Carola;
- Raitakari, Olli T;
- North, Kari E;
- Overvad, Kim;
- Arnett, Donna K;
- Hofman, Albert;
- Lehtimäki, Terho;
- Tjønneland, Anne;
- Uitterlinden, André G;
- Rivadeneira, Fernando;
- Franco, Oscar H;
- German, J Bruce;
- Siscovick, David S;
- Cupples, L Adrienne;
- Ordovás, José M
- et al.
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803424/No data is associated with this publication.
Abstract
Scope
Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.Methods and results
A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10-7) , and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3' of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10-8) such that each serving of low-fat dairy was associated with 0.225 kg m-2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure.Conclusion
Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.