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Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

  • Author(s): Smith, CE
  • Follis, JL
  • Dashti, HS
  • Tanaka, T
  • Graff, M
  • Fretts, AM
  • Kilpeläinen, TO
  • Wojczynski, MK
  • Richardson, K
  • Nalls, MA
  • Schulz, CA
  • Liu, Y
  • Frazier-Wood, AC
  • van Eekelen, E
  • Wang, C
  • de Vries, PS
  • Mikkilä, V
  • Rohde, R
  • Psaty, BM
  • Hansen, T
  • Feitosa, MF
  • Lai, CQ
  • Houston, DK
  • Ferruci, L
  • Ericson, U
  • Wang, Z
  • de Mutsert, R
  • Oddy, WH
  • de Jonge, EAL
  • Seppälä, I
  • Justice, AE
  • Lemaitre, RN
  • Sørensen, TIA
  • Province, MA
  • Parnell, LD
  • Garcia, ME
  • Bandinelli, S
  • Orho-Melander, M
  • Rich, SS
  • Rosendaal, FR
  • Pennell, CE
  • Kiefte-de Jong, JC
  • Kähönen, M
  • Young, KL
  • Pedersen, O
  • Aslibekyan, S
  • Rotter, JI
  • Mook-Kanamori, DO
  • Zillikens, MC
  • Raitakari, OT
  • North, KE
  • Overvad, K
  • Arnett, DK
  • Hofman, A
  • Lehtimäki, T
  • Tjønneland, A
  • Uitterlinden, AG
  • Rivadeneira, F
  • Franco, OH
  • German, JB
  • Siscovick, DS
  • Cupples, LA
  • Ordovás, JM
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803424/
No data is associated with this publication.
Abstract

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10−7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10−8) such that each serving of low-fat dairy was associated with 0.225 kg m−2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.

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