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Computational Protein Design Quantifies Structural Constraints on Amino Acid Covariation

  • Author(s): Kortemme, Tanja
  • Ollikainen, N
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3828131?pdf=render
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Abstract

Amino acid covariation, where the identities of amino acids at different sequence positions are correlated, is a hallmark of naturally occurring proteins. This covariation can arise from multiple factors, including selective pressures for maintaining prote

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