Computational Protein Design Quantifies Structural Constraints on Amino Acid Covariation
- Author(s): Kortemme, Tanja
- Ollikainen, N
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3828131?pdf=render
Amino acid covariation, where the identities of amino acids at different sequence positions are correlated, is a hallmark of naturally occurring proteins. This covariation can arise from multiple factors, including selective pressures for maintaining prote