UC San Diego

Objective

To determine whether dose painting with volumetric modulated arc therapy for high-grade gliomas using 3,4-dihydroxy-6-[¹⁸F]fluoro-l-phenylalanine (¹⁸F-FDOPA) positron emission tomography (PET) could achieve dose-escalated coverage of biological target volumes (BTVs) without increasing the dose to cranial organs at risk (OARs).

Methods

10 patients with high-grade gliomas underwent CT, MRI, and ¹⁸F-FDOPA PET/CT images for post-operative radiation therapy planning. Two volumetric modulated arc therapy plans were retrospectively generated for each patient: a conventional plan with 60 Gy in 30 fractions to the planning target volume delineated on MRI and a dose-escalated plan with a maximum dose of 80 Gy in 30 fractions to BTVs. BTVs were created by thresholding ¹⁸F-FDOPA PET/CT uptake using a linear quadratic model that assumed tracer uptake was linearly related to tumour cell density. The maximum doses and equivalent uniform doses of OARs were compared.

Results

The median volume of the planning target volume receiving at least 95% of the prescribed dose (V _95%) was 99.6% with and 99.5% without dose painting. The median V _95% was >99.2% for BTVs. The maximum doses and equivalent uniform doses to the OARs did not differ significantly between the conventional and dose-painted plans.

Conclusion

Using commercially available treatment planning software, dose painting for high-grade gliomas was feasible with good BTV coverage and no significant change in the dose to OARs.

Advances in knowledge

A novel treatment planning strategy was used to achieve dose painting for gliomas with BTVs obtained from ¹⁸F-FDOPA PET/CT using a radiobiological model.