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Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer.

  • Author(s): Kantoff, PW
  • Gillio, AP
  • McLachlin, JR
  • Bordignon, C
  • Eglitis, MA
  • Kernan, NA
  • Moen, RC
  • Kohn, DB
  • Yu, SF
  • Karson, E
  • et al.
Abstract

Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.

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