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Open Access Publications from the University of California

The future of cancer treatment: will it include immunotherapy?

  • Author(s): Bluestone, Jeffrey A
  • Small, Eric J
  • et al.
Abstract

Negative immune regulatory pathways inhibit anti-cancer T cell responses, preventing effective immune surveillance. Two clinical trials using monoclonal antibodies that antagonize the PD-1/PD-L1 pathway recently reported regression in several tumor types. In one of these trials, efficacy was linked to the expression of the PD-L1 biomarker on tumor cells.

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