The future of cancer treatment: will it include immunotherapy?
- Author(s): Bluestone, Jeffrey A
- Small, Eric J
- et al.
Published Web Locationhttps://doi.org/10.1016/j.ccr.2012.06.009
Negative immune regulatory pathways inhibit anti-cancer T cell responses, preventing effective immune surveillance. Two clinical trials using monoclonal antibodies that antagonize the PD-1/PD-L1 pathway recently reported regression in several tumor types. In one of these trials, efficacy was linked to the expression of the PD-L1 biomarker on tumor cells.