Rotaxane probes for protease detection by129Xe hyperCEST NMR
- Author(s): Slack, CC
- Finbloom, JA
- Jeong, K
- Bruns, CJ
- Wemmer, DE
- Pines, A
- Francis, MB
- et al.
Published Web Locationhttps://doi.org/10.1039/c6cc09302g
© The Royal Society of Chemistry. We report a CB6 rotaxane for the129Xe hyperCEST NMR detection of matrix metalloprotease 2 (MMP-2) activity. MMP-2 is overexpressed in cancer tissue, and hence is a cancer marker. A peptide containing an MMP-2 recognition sequence was incorporated into the rotaxane, synthesized via CB6-promoted click chemistry. Upon cleavage of the rotaxane by MMP-2, CB6 became accessible for129Xe@CB6 interactions, leading to protease-responsive hyperCEST activation.
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