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Open Access Publications from the University of California

Rotaxane probes for protease detection by129Xe hyperCEST NMR

  • Author(s): Slack, CC
  • Finbloom, JA
  • Jeong, K
  • Bruns, CJ
  • Wemmer, DE
  • Pines, A
  • Francis, MB
  • et al.

© The Royal Society of Chemistry. We report a CB6 rotaxane for the129Xe hyperCEST NMR detection of matrix metalloprotease 2 (MMP-2) activity. MMP-2 is overexpressed in cancer tissue, and hence is a cancer marker. A peptide containing an MMP-2 recognition sequence was incorporated into the rotaxane, synthesized via CB6-promoted click chemistry. Upon cleavage of the rotaxane by MMP-2, CB6 became accessible for129Xe@CB6 interactions, leading to protease-responsive hyperCEST activation.

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