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Rotaxane probes for protease detection by 129Xe hyperCEST NMR.

  • Author(s): Slack, Clancy C
  • Finbloom, Joel A
  • Jeong, Keunhong
  • Bruns, Carson J
  • Wemmer, David E
  • Pines, Alexander
  • Francis, Matthew B
  • et al.

We report a CB6 rotaxane for the 129Xe hyperCEST NMR detection of matrix metalloprotease 2 (MMP-2) activity. MMP-2 is overexpressed in cancer tissue, and hence is a cancer marker. A peptide containing an MMP-2 recognition sequence was incorporated into the rotaxane, synthesized via CB6-promoted click chemistry. Upon cleavage of the rotaxane by MMP-2, CB6 became accessible for 129Xe@CB6 interactions, leading to protease-responsive hyperCEST activation.

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