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The Nicaraguan pediatric influenza cohort study: design, methods, use of technology, and compliance.

  • Author(s): Gordon, Aubree
  • Kuan, Guillermina
  • Aviles, William
  • Sanchez, Nery
  • Ojeda, Sergio
  • Lopez, Brenda
  • Gresh, Lionel
  • Balmaseda, Angel
  • Harris, Eva
  • et al.
Abstract

Background

Influenza causes substantial morbidity and mortality worldwide, yet few data exist on influenza infection rates in tropical, developing countries. In 2011, we established the Nicaraguan Pediatric Influenza Cohort Study (NPICS) to study the burden and seasonality of influenza in Nicaraguan children. Here we describe the study design, methods, and participation data of the NPICS for 2011-2013.

Methods/design

A total of 1532 children aged 0 to 12 years were enrolled into the study in 2011, and an additional 401 children were enrolled between 2012 and 2013. Children were provided with all of their medical care through the study, and data on medical visits were recorded systematically. A number of surveys were conducted together with a blood sample annually, including a height and weight measurement, a socio-economic status and risk factor survey, and a breastfeeding survey.

Discussion

Unique features of our study include the customized low-cost, open-source informatics system as well as the development of methods to leverage infrastructure and resources by conducting multiple studies in the same setting while maximizing protocol adherence and quality control. These methods should be useful to others conducting large cohort studies, particularly in low-resource settings.

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