Deep hypothermia for the treatment of refractory status epilepticus
- Author(s): Niquet, J
- Baldwin, R
- Gezalian, M
- Wasterlain, CG
- et al.
Published Web Locationhttps://doi.org/10.1016/j.yebeh.2015.06.028
© 2015 . In a rat model of status epilepticus (SE) induced by lithium and pilocarpine and refractory to midazolam, deep hypothermia (20. °C for 30. min) reduced EEG power over 50-fold, stopped SE within 12. min, and reduced EEG spikes by 87%. Hypothermia deserves further investigation as a treatment of last resort for refractory SE.This article is part of a Special Issue entitled "Status Epilepticus".