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Open Access Publications from the University of California

Deep hypothermia for the treatment of refractory status epilepticus

  • Author(s): Niquet, J
  • Baldwin, R
  • Gezalian, M
  • Wasterlain, CG
  • et al.

© 2015 . In a rat model of status epilepticus (SE) induced by lithium and pilocarpine and refractory to midazolam, deep hypothermia (20. °C for 30. min) reduced EEG power over 50-fold, stopped SE within 12. min, and reduced EEG spikes by 87%. Hypothermia deserves further investigation as a treatment of last resort for refractory SE.This article is part of a Special Issue entitled "Status Epilepticus".

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