Bukhryakov, Konstantin V; Schrock, Richard R; Hoveyda, Amir H; Müller, Peter; Becker, Jonathan

doi:10.1021/acs.orglett.7b01062

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Synthesis of 2,6-Hexa-tert-butylterphenyl Derivatives, 2,6-(2,4,6‑t‑Bu3C6H2)2C6H3X, where X = I, Li, OH, SH, N3, or NH2

2017

Published Web Location

https://doi.org/10.1021/acs.orglett.7b01062

Abstract

A "double benzyne" reaction between 1,3-dichloro-2-iodobenzene and 2,4,6-t-Bu₃C₆H₂MgBr followed by the addition of iodine led to 2,6-(2,4,6-t-Bu₃C₆H₂)₂C₆H₃I (HTBTI) in 65% yield. Lithiation of HTBTI with Li-t-Bu gave Li(Et₂O)₂HTBT from which HTBTSH, HTBTN₃, HTBTNH₂, and HTBTOH were prepared. An X-ray structure of W(OHTBT)₂Cl₄ shows that the two HTBTO ligands are trans to one another with the t-Bu₃C₆H₂ groups on one HTBTO interdigitated with the t-Bu₃C₆H₂ groups on the other HTBTO.

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Synthesis of 2,6-Hexa-tert-butylterphenyl Derivatives, 2,6-(2,4,6‑t‑Bu3C6H2)2­C6H3X, where X = I, Li, OH, SH, N3, or NH2

Published Web Location

Synthesis of 2,6-Hexa-tert-butylterphenyl Derivatives, 2,6-(2,4,6‑t‑Bu3C6H2)2C6H3X, where X = I, Li, OH, SH, N3, or NH2