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Open Access Publications from the University of California

BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor

  • Author(s): Klein, Ophir
  • Ho, Sunita
  • Biehs, B
  • Hu, JKH
  • Strauli, NB
  • Sangiorgi, E
  • Jung, H
  • Heber, RP
  • Goodwin, AF
  • Dasen, JS
  • Capecchi, MR
  • et al.

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The polycomb group gene Bmi1 is required for maintenance of adult stem cells in many organs. Inactivation of Bmi1 leads to impaired stem cell self-renewal due to deregulated gene expression. One critical target of BMI1 is Ink4a/Arf, which encodes the cell-

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