A multi-scale method for dynamics simulation in continuum solvent models. I: Finite-difference algorithm for Navier-Stokes equation
- Author(s): Xiao, L
- Cai, Q
- Li, Z
- Zhao, H
- Luo, R
- et al.
Published Web Locationhttps://doi.org/10.1016/j.cplett.2014.10.033
A multi-scale framework is proposed for more realistic molecular dynamics simulations in continuum solvent models by coupling a molecular mechanics treatment of solute with a fluid mechanics treatment of solvent. This article reports our initial efforts to formulate the physical concepts necessary for coupling the two mechanics and develop a 3D numerical algorithm to simulate the solvent fluid via the Navier-Stokes equation. The numerical algorithm was validated with multiple test cases. The validation shows that the algorithm is effective and stable, with observed accuracy consistent with our design.