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A multi-scale method for dynamics simulation in continuum solvent models. I: Finite-difference algorithm for Navier-Stokes equation

  • Author(s): Xiao, L
  • Cai, Q
  • Li, Z
  • Zhao, H
  • Luo, R
  • et al.
Abstract

A multi-scale framework is proposed for more realistic molecular dynamics simulations in continuum solvent models by coupling a molecular mechanics treatment of solute with a fluid mechanics treatment of solvent. This article reports our initial efforts to formulate the physical concepts necessary for coupling the two mechanics and develop a 3D numerical algorithm to simulate the solvent fluid via the Navier-Stokes equation. The numerical algorithm was validated with multiple test cases. The validation shows that the algorithm is effective and stable, with observed accuracy consistent with our design.

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