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Open Access Publications from the University of California

EGFR blockade prevents glioma escape from BRAFV600E targeted therapy

  • Author(s): Weiss, William
  • Prados, Michael
  • Nicolaides, Theodore
  • Yao, TW
  • Zhang, J
  • Weiss, WA
  • David, C
  • et al.

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Mutational activation of BRAF (BRAFV600E) occurs in pediatric glioma and drives aberrant MAPK signaling independently of upstream cues. Targeted monotherapy against BRAFV600E displays efficacy in pre-clinical models of glioma, however

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