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EGFR blockade prevents glioma escape from BRAFV600E targeted therapy
- Author(s): Weiss, William
- Prados, Michael
- Nicolaides, Theodore
- Yao, TW
- Zhang, J
- Weiss, WA
- David, C
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4673141?pdf=render
No data is associated with this publication.
Mutational activation of BRAF (BRAFV600E) occurs in pediatric glioma and drives aberrant MAPK signaling independently of upstream cues. Targeted monotherapy against BRAFV600E displays efficacy in pre-clinical models of glioma, however
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