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The Free Energy Profile of Tubulin Straight-Bent Conformational Changes, with Implications for Microtubule Assembly and Drug Discovery

  • Author(s): Jacobson, Matthew
  • Agard, David
  • Peng, LX
  • Hsu, MT
  • Bonomi, M
  • Jacobson, MP
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3916224?pdf=render
No data is associated with this publication.
Abstract

αβ-tubulin dimers need to convert between a 'bent' conformation observed for free dimers in solution and a 'straight' conformation required for incorporation into the microtubule lattice. Here, we investigate the free energy landscape of αβ-tubulin using m

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