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A cephalosporin-chemiluminescent conjugate increases beta-lactamase detection sensitivity by four orders of magnitude.

  • Author(s): Maity, Santanu
  • Wang, Xiaojian
  • Das, Subhamoy
  • He, Maomao
  • Riley, Lee W
  • Murthy, Niren
  • et al.

Published Web Location

https://pubs.rsc.org/en/content/articlelanding/2020/CC/C9CC09498A#!divAbstract
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Abstract

The expression of beta-lactamases in bacteria is a central cause of drug resistance. In this report, we present a beta-lactamase chemiluminescent probe, termed CCP, which can for the first time detect beta-lactamase activity via chemiluminescence and can detect beta lactamase with a sensitivity that is 4-orders of magnitude higher than the commercially available fluorescent lactamase substrate fluorocillin.

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