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Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis
Published Web Location
https://doi.org/10.1038/nn.3295Abstract
Treatment of pain with morphine leads to paradoxical hyperalgesia. The authors provide evidence that morphine-induced hyperalgesia is a result of downregulation of the chloride transporter KCC2 in spinal lamina I neurons. Microglial expression of P2X4 receptors and release of BDNF may underlie this change in neuronal chloride homeostasis and morphine-induced hyperalgesia.
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