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The development of cryo-EM into a mainstream structural biology technique
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913480/No data is associated with this publication.
Abstract
Single-particle cryo-electron microscopy (cryo-EM) has emerged over the last two decades as a technique capable of studying challenging systems that otherwise defy structural characterization. Recent technical advances have resulted in a 'quantum leap' in applicability, throughput and achievable resolution that has gained this technique worldwide attention. Here I discuss some of the major historical landmarks in the development of the cryo-EM field, ultimately leading to its present success.
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