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Bioinformatic Software Library for Circadian Analysis

  • Author(s): Ceglia, Nicholas Joseph
  • Advisor(s): Baldi, Pierre F
  • et al.
Abstract

Circadian oscillations play a fundamental role in many biological processes including cell metabolism and cell cycle. As such, interest in understanding these molecular oscillations has generated an increasingly large collection of circadian omic data. These studies have demonstrated the remarkable plasticity with which the set of oscillating molecular species within a cell are selected. These large shifts in oscillating species are known as circadian reprogramming events. These events have been observed across experimental condition, tissue, and species. While many of these studies have made tissue or condition specific conclusions, a consolidated framework of software tools and a central repository of data has become necessary to answer questions about the orchestration of these reprogramming events.

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