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50 years in the making: acp3U, an amino-acid-containing nucleoside, links N-glycans and RNA in glycoRNA.
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https://doi.org/10.1016/j.molcel.2024.09.014Abstract
In a recent publication in Cell, Xie et al.1 report a sensitive and scalable method for the detection and characterization of native glycoRNAs and identify acp3U, an abundant modified nucleoside discovered 50 years ago in tRNAPhe, as one of the primary attachment sites for N-glycans.
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