Skip to main content
eScholarship
Open Access Publications from the University of California

Mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort

  • Author(s): Wade, BSC
  • Valcour, VG
  • Wendelken-Riegelhaupt, L
  • Esmaeili-Firidouni, P
  • Joshi, SH
  • Wang, Y
  • Thompson, PM
  • et al.
Abstract

© 2015 IEEE. Over 50% of HIV+ individuals exhibit neurocognitive impairment and subcortical atrophy, but the pattern of brain abnormalities associated with HIV is still poorly understood. Using parametric surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 HIV+ participants and 31 uninfected controls. The thalamus, corpus striatum, hippocampus, amygdala, brainstem, callosum and ventricles were segmented from brain MRIs. To investigate subcortical shape, we analyzed the Jacobian determinant (JD) and radial distances (RD) for structure surfaces. We also investigated effects of nadir CD4+ T-cell counts, viral load, and illness duration on subcortical morphology. Our results characterize subcortical morphometry in older HIV+ people, where participants showed significant volumetric enlargements in the thalamus, left pallidum and the ventricles while showing a reduction in the callosum. Further, RD maps revealed atrophy of the left thalamus and expansion of the brainstem in HIV. RD and JD maps of the right pallidum identified tissue expansion associated with illness duration while the left pallidum showed anterior atrophy and posterior expansion associated with viral load.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View