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Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.

  • Author(s): Finkbeiner, Steven
  • Kim, H-J
  • Raphael, AR
  • LaDow, ES
  • McGurk, L
  • Weber, RA
  • Trojanowski, JQ
  • Lee, VM-Y
  • Gitler, AD
  • Bonini, NM
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3934366?pdf=render
No data is associated with this publication.
Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal, late-onset neurodegenerative disease primarily affecting motor neurons. A unifying feature of many proteins associated with ALS, including TDP-43 and ataxin-2, is that they localize to stress granules. Unexpe

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