Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.
- Author(s): Finkbeiner, Steven
- Kim, H-J
- Raphael, AR
- LaDow, ES
- McGurk, L
- Weber, RA
- Trojanowski, JQ
- Lee, VM-Y
- Gitler, AD
- Bonini, NM
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3934366?pdf=render
Amyotrophic lateral sclerosis (ALS) is a fatal, late-onset neurodegenerative disease primarily affecting motor neurons. A unifying feature of many proteins associated with ALS, including TDP-43 and ataxin-2, is that they localize to stress granules. Unexpe
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