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Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial
- Oldenburg, Catherine E;
- Hinterwirth, Armin;
- Sié, Ali;
- Coulibaly, Boubacar;
- Ouermi, Lucienne;
- Dah, Clarisse;
- Tapsoba, Charlemagne;
- Cummings, Milo E;
- Zhong, Lina;
- Chen, Cindi;
- Sarkar, Samarpita;
- Bärnighausen, Till;
- Lietman, Thomas M;
- Keenan, Jeremy D;
- Doan, Thuy
Published Web Location
https://doi.org/10.1093/cid/ciz455Abstract
We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.
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