A water-soluble iron-porphyrin complex capable of rescuing CO-poisoned red blood cells.
- Author(s): Droege, Daniel G;
- Johnstone, Timothy C
- et al.
Published Web Locationhttps://doi.org/10.1039/d1cc05542a
We describe herein a small-molecule platform that exhibits key properties needed by an antidote for CO poisoning. The design features an iron-porphyrin complex with bulky substituents above and below the macrocyclic plane to provide a hydrophobic pocket for CO binding and to prevent the formation of inactive oxo-bridged dimers. Peripheral charged groups impart water solubility. We demonstrate that the Fe(II) complex of a porphyrin with 2,6-diphenyl-4-sulfophenyl meso substituents can bind CO, stoichiometrically sequester CO from carboxyhemoglobin, and rescue CO-poisoned red blood cells.