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Pharmacological brake-release of mRNA translation enhances cognitive memory

  • Author(s): Walter, Peter
  • Renslo, Adam
  • Arkin, Michelle
  • Sidrauski, C
  • Acosta-Alvear, D
  • Khoutorsky, A
  • Vedantham, P
  • Hearn, BR
  • Li, H
  • Gamache, K
  • Gallagher, CM
  • Ang, KKH
  • Wilson, C
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3667625?pdf=render
No data is associated with this publication.
Abstract

Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating a unique

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