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Substrate deconstruction and the nonadditivity of enzyme recognition

  • Author(s): Shoichet, Brian
  • Barelier, S
  • Cummings, JA
  • Rauwerdink, AM
  • Hitchcock, DS
  • Farelli, JD
  • Almo, SC
  • Raushel, FM
  • Allen, KN
  • Shoichet, BK
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4046767?pdf=render
No data is associated with this publication.
Abstract

Predicting substrates for enzymes of unknown function is a major postgenomic challenge. Substrate discovery, like inhibitor discovery, is constrained by our ability to explore chemotypes; it would be expanded by orders of magnitude if reactive sites could

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