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Substrate deconstruction and the nonadditivity of enzyme recognition
Published Web Location
http://europepmc.org/articles/PMC4046767?pdf=renderNo data is associated with this publication.
Abstract
Predicting substrates for enzymes of unknown function is a major postgenomic challenge. Substrate discovery, like inhibitor discovery, is constrained by our ability to explore chemotypes; it would be expanded by orders of magnitude if reactive sites could
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