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Substrate deconstruction and the nonadditivity of enzyme recognition
- Author(s): Shoichet, Brian
- Barelier, S
- Cummings, JA
- Rauwerdink, AM
- Hitchcock, DS
- Farelli, JD
- Almo, SC
- Raushel, FM
- Allen, KN
- Shoichet, BK
- et al.
Published Web Location
http://europepmc.org/articles/PMC4046767?pdf=renderNo data is associated with this publication.
Abstract
Predicting substrates for enzymes of unknown function is a major postgenomic challenge. Substrate discovery, like inhibitor discovery, is constrained by our ability to explore chemotypes; it would be expanded by orders of magnitude if reactive sites could
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