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Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G

  • Author(s): Verkman, Alan
  • Asavapanumas, N
  • Ratelade, J
  • Papadopoulos, MC
  • Bennett, JL
  • Levin, MH
  • Verkman, AS
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3909205?pdf=render
No data is associated with this publication.
Abstract

Background: Although optic neuritis (ON) is a defining feature of neuromyelitis optica (NMO), appropriate animal models of NMO ON are lacking. Most NMO patients are seropositive for immunoglobulin G autoantibodies (NMO-IgG) against the astrocyte water chan

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