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PD-1 blockade induces responses by inhibiting adaptive immune resistance
- Tumeh, Paul C;
- Harview, Christina L;
- Yearley, Jennifer H;
- Shintaku, I Peter;
- Taylor, Emma JM;
- Robert, Lidia;
- Chmielowski, Bartosz;
- Spasic, Marko;
- Henry, Gina;
- Ciobanu, Voicu;
- West, Alisha N;
- Carmona, Manuel;
- Kivork, Christine;
- Seja, Elizabeth;
- Cherry, Grace;
- Gutierrez, Antonio J;
- Grogan, Tristan R;
- Mateus, Christine;
- Tomasic, Gorana;
- Glaspy, John A;
- Emerson, Ryan O;
- Robins, Harlan;
- Pierce, Robert H;
- Elashoff, David A;
- Robert, Caroline;
- Ribas, Antoni
Published Web Location
https://doi.org/10.1038/nature13954Abstract
The dynamics of T-cell responses are investigated in tumour tissue from patients with advanced melanoma who were treated with a PD-1-blocking monoclonal antibody, revealing that clinical efficacy of the treatment correlates with increased frequencies of pre-existing CD8+ T cells and PD-1 and PD-L1 expression.
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