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ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing
- Jacob, Yannick;
- Feng, Suhua;
- LeBlanc, Chantal A;
- Bernatavichute, Yana V;
- Stroud, Hume;
- Cokus, Shawn;
- Johnson, Lianna M;
- Pellegrini, Matteo;
- Jacobsen, Steven E;
- Michaels, Scott D
Published Web Location
https://doi.org/10.1038/nsmb.1611Abstract
Covalent histone modifications can affect the structure of chromatin. Expression of underlying monomethylated histone H3K27 is associated with chromocenters in Arabidopsis, but its presence is unaffected by mutations in the expected methyltransferases. Data now indicate that this modification is catalyzed by Arabidopsis ATRX5 and ATXR6 and is required for silencing, but in a pathway independent of that involving DNA methyltransferases.
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