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A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

  • Author(s): Sali, Andrej
  • Fischbach, Michael
  • Medema, MH
  • Cimermancic, P
  • Takano, E
  • Fischbach, MA
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4256081?pdf=render
No data is associated with this publication.
Abstract

© 2014 Medema et al.Bacterial secondary metabolites are widely used as antibiotics, anticancer drugs, insecticides and food additives. Attempts to engineer their biosynthetic gene clusters (BGCs) to produce unnatural metabolites with improved properties ar

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