Association Between Frailty and Components of the Frailty Phenotype With Modifiable Risk Factors and Antiretroviral Therapy.
- Author(s): Erlandson, Kristine M
- Wu, Kunling
- Koletar, Susan L
- Kalayjian, Robert C
- Ellis, Ronald J
- Taiwo, Babafemi
- Palella, Frank J
- Tassiopoulos, Katherine
- et al.
Published Web Locationhttps://doi.org/10.1093/infdis/jix063
The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV)-infected adults has not been well described. HIV-infected participants aged ≥40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.