Quinone replacements for small molecule insulin mimics.
- Author(s): Pirrung, Michael C
- Deng, Liu
- Lin, Bo
- Webster, Nicholas J G
- et al.
A 3-stannylindole was coupled with a 2-bromokojic acid to give an (indolyl)kojic acid that activates the insulin receptor in cell-based assays. This structure represents a hybrid between two Aspergillus natural products, demethylasterriquinone B1 and kojic acid.