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Quinone replacements for small molecule insulin mimics.

  • Author(s): Pirrung, Michael C;
  • Deng, Liu;
  • Lin, Bo;
  • Webster, Nicholas J G
  • et al.
Abstract

A 3-stannylindole was coupled with a 2-bromokojic acid to give an (indolyl)kojic acid that activates the insulin receptor in cell-based assays. This structure represents a hybrid between two Aspergillus natural products, demethylasterriquinone B1 and kojic acid.

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