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Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: Pharmacokinetics and correlation with digital perfusion
- Author(s): Boin, Francesco;
- Shah, AA;
- Schiopu, E;
- Hummers, LK;
- Wade, M;
- Phillips, K;
- Anderson, C;
- Wise, R;
- Seibold, JR;
- Wigley, F
- et al.
Published Web Location
http://europepmc.org/articles/PMC5011881?pdf=renderNo data is associated with this publication.
Abstract
Introduction: Treprostinil diethanolamine is an innovative salt form of the prostacyclin analogue, treprostinil sodium, developed as an oral sustained release (SR) osmotic tablet. The availability of a formulation permitting convenient systemic delivery mi
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