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Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells
- Author(s): Jablons, David
- You, B
- Yang, YL
- Xu, Z
- Dai, Y
- Liu, S
- Mao, JH
- Tetsu, O
- Li, H
- Jablons, DM
- You, L
- et al.
Published Web Location
http://europepmc.org/articles/PMC4414195?pdf=renderNo data is associated with this publication.
Abstract
Alterations of the EGFR/ERK and Hippo/YAP pathway have been found in nonsmall cell lung cancer (NSCLC). Herein, we show that ERK1 and ERK2 have an effect on the Hippo/YAP pathway in human NSCLC cells. Firstly, inhibition of ERK1/2 by siRNA or small-molecul
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