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All or nothing: Protein complexes flip essentiality between distantly related eukaryotes

  • Author(s): Krogan, Nevan
  • Ryan, CJ
  • Krogan, NJ
  • Cunningham, P
  • Cagney, G
  • et al.

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In the budding yeast Saccharomyces cerevisiae, the subunits of any given protein complex are either mostly essential or mostly nonessential, suggesting that essentiality is a property of molecular machines rather than individual components. There are excep

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