Inhibition of ornithine decarboxylase alters neurological responsiveness to a tremorigen.
- Author(s): Tilson, HA
- Emerich, D
- Bondy, SC
- et al.
Published Web Locationhttps://doi.org/10.1016/0006-8993(86)90267-2
Difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC; 200-800 mg/kg, s.c.), to rats has no detectable behavioral effects using a battery of tests to assess sensorimotor function. In contrast, the induction of tremor by chlordecone, a neurotoxic agent that affects neuronal ionic processes, is significantly attenuated by pretreatment with DFMO. The effects of DFMO on chlordecone-induced tremor were reversed by pretreatment with putrescine. DFMO had no effects on p,p'-DDT, a tremorigen having a mechanism of action different from chlordecone. These findings imply that polyamines may play a role in select neuronal processes.