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Let It Go and Open Up, an Ensemble of Ion Channel Active States
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https://doi.org/10.1016/j.cell.2016.01.037Abstract
Ligand binding usually moves the target protein from an ensemble of inactive states to a well-defined active conformation. Matthies et al. flip this scheme around, finding that, for the magnesium channel CorA, loss of ligand binding induces an ensemble of conformations that turn the channel on.
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