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Gold(I)-catalyzed enantioselective bromocyclization reactions of allenes

  • Author(s): Miles, DH
  • Veguillas, M
  • Toste, FD
  • et al.

Published Web Location

https://doi.org/10.1039/c3sc50811k
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Abstract

The enantioselective bromocyclization of allenes is accomplished through the use of a chiral dinuclear gold complex and/or chiral phosphate anions in the presence of an N-bromolactam as an electrophilic bromine source. This method provides access to heterocyclic vinyl bromides with an allylic stereocenter in excellent yield and enantioselectivity. These enantioenriched vinyl bromides may serve as a handle for further derivatization via cross-coupling reactions. © 2013 The Royal Society of Chemistry.

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This item is under embargo until March 17, 2021.