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Gold(I)-catalyzed enantioselective bromocyclization reactions of allenes
- Author(s): Miles, DH
- Veguillas, M
- Toste, FD
- et al.
Published Web Location
https://doi.org/10.1039/c3sc50811kNo data is associated with this publication.
Abstract
The enantioselective bromocyclization of allenes is accomplished through the use of a chiral dinuclear gold complex and/or chiral phosphate anions in the presence of an N-bromolactam as an electrophilic bromine source. This method provides access to heterocyclic vinyl bromides with an allylic stereocenter in excellent yield and enantioselectivity. These enantioenriched vinyl bromides may serve as a handle for further derivatization via cross-coupling reactions. © 2013 The Royal Society of Chemistry.