Skip to main content
Open Access Publications from the University of California

Gold(I)-catalyzed enantioselective bromocyclization reactions of allenes

  • Author(s): Miles, DH
  • Veguillas, M
  • Toste, FD
  • et al.

Published Web Location
No data is associated with this publication.

The enantioselective bromocyclization of allenes is accomplished through the use of a chiral dinuclear gold complex and/or chiral phosphate anions in the presence of an N-bromolactam as an electrophilic bromine source. This method provides access to heterocyclic vinyl bromides with an allylic stereocenter in excellent yield and enantioselectivity. These enantioenriched vinyl bromides may serve as a handle for further derivatization via cross-coupling reactions. © 2013 The Royal Society of Chemistry.

Main Content

This item is under embargo until March 17, 2021.