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Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome.

  • Author(s): Petersen, Melissa
  • Zhang, Fan
  • Krinsky-McHale, Sharon J
  • Silverman, Wayne
  • Lee, Joseph H
  • Pang, Deborah
  • Hall, James
  • Schupf, Nicole
  • O'Bryant, Sid E
  • et al.


We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS).


Plasma samples were obtained from 398 members of a community-based cohort of adults with DS. A total of n = 186 participants were determined to be non-demented and without mild cognitive impairment (MCI) at baseline and throughout follow-up; n = 50 had prevalent MCI; n = 42 had prevalent AD.


The proteomic profile yielded an area under the curve (AUC) of 0.92, sensitivity (SN) = 0.80, and specificity (SP) = 0.98 detecting prevalent MCI. For detecting prevalent AD, the proteomic profile yielded an AUC of 0.89, SN = 0.81, and SP = 0.97. The overall profile closely resembled our previously published profile of AD in the general population.


These data provide evidence of the applicability of our blood-based algorithm for detecting MCI/AD among adults with DS.

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