- Main
Genome Wide Conditional Mouse Knockout Resources.
- Kaloff, C;
- Anastassiadis, K;
- Ayadi, A;
- Baldock, R;
- Beig, J;
- Birling, M-C;
- Bradley, A;
- Brown, S;
- Bürger, A;
- Bushell, W;
- Chiani, F;
- Collins, F;
- Doe, B;
- Eppig, J;
- Finnel, R;
- Fletcher, C;
- Flicek, P;
- Fray, M;
- Friedel, R;
- Gambadoro, A;
- Gates, H;
- Hansen, J;
- Herault, Y;
- Hicks, G;
- Hörlein, A;
- Hrabé de Angelis, M;
- Iyer, V;
- de Jong, P;
- Koscielny, G;
- Kühn, R;
- Liu, P;
- Lloyd, K;
- Lopez, R;
- Marschall, S;
- Martínez, S;
- McKerlie, C;
- Meehan, T;
- von Melchner, H;
- Moore, M;
- Murray, S;
- Nagy, A;
- Nutter, Lmj;
- Pavlovic, G;
- Pombero, A;
- Prosser, H;
- Ramirez-Solis, R;
- Ringwald, M;
- Rosen, B;
- Rosenthal, N;
- Rossant, J;
- Ruiz Noppinger, P;
- Ryder, E;
- Skarnes, W;
- Schick, J;
- Schnütgen, F;
- Schofield, P;
- Seisenberger, C;
- Selloum, M;
- Smedley, D;
- Simpson, E;
- Stewart, A;
- Teboul, L;
- Tocchini Valentini, G;
- Valenzuela, D;
- West, A;
- Wurst, W
- et al.
Published Web Location
https://doi.org/10.1016/j.ddmod.2017.08.002Abstract
The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6,000 mutant mouse strains have been produced by the IKMC and mostly the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 inducible cre-driver mouse strains in a C57BL/6 background. Complementing the cre-driver resource, a collection of comprising 27 cre-driver rAAVs has also been produced. The resources can be easily accessed at the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds that enables the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.
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