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Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging

et al.

Published Web Location

https://doi.org/10.1038/nn.3324
Creative Commons 'BY' version 4.0 license
Abstract

Age-related cognitive decline is paralleled by two other prominent brain changes: structural atrophy prominent in medial prefrontal cortex (mPFC) and disrupted non-rapid eye movement (NREM) slow-wave sleep (SWS). This study establishes an interaction between these factors, demonstrating that the extent of mPFC atrophy predicts the degree of impaired NREM SWS quality, thereby compromising hippocampal-dependent memory consolidation in the aging human brain.

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